Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Incompatible with oxidizing agents and water. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of PyBOP (CAS: 128625-52-5) with high quality. Ruifu supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase PyBOP, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | PyBOP |
| Synonyms | 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate; (Benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate; 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium Hexafluorophosphate |
| Stock Status | In Stock, Mass Production |
| CAS Number | 128625-52-5 |
| Molecular Formula | C18H28F6N6OP2 |
| Molecular Weight | 520.40 g/mol |
| Melting Point | 150.0~158.0℃ |
| Density | 1.438 at 20℃ |
| Sensitive | Light Sensitive, Moisture Sensitive, Heat Sensitive |
| Solubility | Soluble in Chloroform |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Melting Point | 150.0~158.0℃ | 154.0~158.0℃ |
| Loss on Drying | <0.50% | 0.09% |
| Heavy Metals (Pb) | ≤20ppm | <20ppm |
| Purity / Analysis Method | >99.0% (HPLC) | 99.8% |
| Clarity of Solution | 1 mmole in 2 ml DMF Clear Solution | Complies |
| Infrared Spectrum | Conforms to Structure | Complies |
| Proton NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
128625-52-5 - Risk and Safety:
Application:
Hazard Symbols Xi - Irritant Risk Codes R37/38 - Irritating to respiratory system and skin. R44 - Risk of explosion if heated under confinement R36/37/38 - Irritating to eyes, respiratory system and skin. Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection UN IDs UN 1325 4.1/PG 2 WGK Germany 3 FLUKA BRAND F CODES 8-10-21 HS Code 2933990099 Hazard Note Irritant1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate (PyBOP) (CAS: 128625-52-5)is one of the most convenient peptide coupling reagents utilized in solid phase peptide synthesis without carcinogenic by-products. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent. It has reactivity similar to BOP, but its byproduct is not highly carcinogenic. PyBOP is especially suitable for solid-phase peptide synthesis, avoids racemization. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations. Analogs of BOP coupling reagents, but do not form carcinogens HMPA is a by-product. May be used in place of BOP in peptide synthesis without loss of coupling efficiency. Coupling reactions are rapid, being nearly complete within a few minutes. Especially useful for cyclization steps for the activation of hindered amino acid. Reagent for: Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization; Generation of endocrine disruptor chemical binders; Cycloaddition to template-assembled multivalent peptide conjugates.Test Method:
1. Instruments and reagents: LC-10AVP high performance liquid chromatograph; SPD-10AVP detector; Acetonitrile (chromatographic pure) 2. Operation steps: according to high performance liquid chromatography determination. a. Chromatographic conditions: octadecylsilane bonded silica gel was used as filler (150*4.6mm*5.0μm); Using Acetonitrile: Water = 3:2 as mobile phase; The detection wavelength was 258nm. Column temperature: 25℃; Flow rate: 0.5ml/min; The number of theoretical plates should be no less than 2000 according to the main peak of PyBOP. b. Determination method: Take this product and add mobile phase to make a solution containing PyBOP 100ug per 1ml as the test product solution. 20μl of the test solution was injected into the chromatograph, and the chromatogram was recorded to 2 times the retention time of the principal component peak. c. Results: This product is calculated as a dry product, containing no less than 99.0% PyBOP.